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RNAiiRNA interference̗{RNAƂjͤ{RNAƑIzmRNA錻ۡRNAi@ͤ̌ۂ𗘗pĐlHIɓ{RNA𓱓邱Ƃɂ褔Cӂ`q̔}@[1]ݽRNA@⺻گ݂RNAï`Ԃƍl
ʏ`q̋@\jQF̈`qj󂷂邱ƂōsĂRNAi@͂̂悤ȔώGȑ͕KvȂz񂳂m邱Ƃł΍RNA𓱓Ȃǂ̊ȕւȎ@ň`q̋@\𒲂ׂ邱ƂłۼުɂđSzm邱Ƃ̂łłͤt`wI͂̑xグ傫ȗv̈‚ƂȂSȋ@\rƂ͂ȂȂƤٓIȉelKvȂǂ̖
1998Nح̧̈łِCaenorhabditis elegans (C. elegans)pĤݽƱݽ̍RNAꂼ̒PRNA傫ȑjQʂ邱Ƃ[2]̌ʂͤWImRNAƂȂǂPɱݽmRNA1:1ŒtđjQ̂ł͂Ȃ炩̑ߒ܂ނyfI‚Ƃ\zꂽ̌RNase IIÏłDicerɂĤ{RNAsiRNAismall interfering RNAjƌĂ΂21-23 nt̒Z3'ˏo^{RNAɐؒf邱ƤsiRNAƂ‚̒`琬RNA`̂łRISĈėpȂ瑊IȔzmRNA𕪉邱Ƃ킩Ă
2001NɂMזEsiRNA𓱓邱ƂŤ܂ŖƂȂĂ{RNAˑòݷŰ̔邱Ƃł[3]ɂ褈`qÉpւ̊҂܂ĂRNAi@\yɎ܂ő̐ŕۑĂ顂̐wIȈӋ`ƂĂٽȂǂɑ΂h@\ƂiĂƂ񏥂Ă顂ɤF̍č\Ȃǂɂւ”\꤂܂stRNAȂǍp@\̈ꕔLmiRNAߒ̈`qsĂ邱ƂȂǂ炩ƂȂ褏qRNAʂ@\ɒڂW܂邫̈‚ƂȂ܂ypłͤFұұ۸`RNAi̋@\֗^Ă邱Ƃ񍐂Ă
2006Nح̧ڲޥ۰RNAǐтɰِww܂
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Fire A, Xu S, Montgomery M, Kostas S, Driver S, Mello C (1998). gPotent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansh. Nature 391 (6669): 806?811. doi:10.1038/35888. 

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1. Mahmood-ur-Rahman, Ali I, Husnain T, Riazuddin S. (2008). gRNA interference: the story of gene silencing in plants and humansh. Biotechnol Adv. 26 (3): 202-209. doi:10.1016/j.biotechadv.2007.12.002. 
2. Fire A, Xu S, Montgomery M, Kostas S, Driver S, Mello C (1998). gPotent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansh. Nature 391 (6669): 806?811. doi:10.1038/35888. 
3. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. (2001). gDuplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.h. Nature 411 (6836): 494-498. doi:10.1038/35078107. 

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